Volumen: 19 # Number : 2
Publication Date : Mayo - Agosto Year: 2015
Lupus anticoagulant detection in women with
obstetric complications: Sensitivity and Specificity of the test
Authors: Avigliano AL, Grand BE.
Abstract: Lupus anticoagulant (LA) is one of the laboratory
criteria for the diagnosis of antiphospholipid syndrome.
To detect the presence of LA, ISTH recommends
performing two assays based on different
principles. Our LA profile includes dilute russell viper
venom time (dRVVT) and two different activated
partial thromboplastin time (aPTT) reagents. We
performed a home made reagent for platelet neutralization
procedure (PNP)-aPTT and dRVVT. The aim
of the study was to evaluate sensitivity (S) and specificity
(SP) of aPTT and dRVVT in women with a
history of placenta mediated complications.172/287
samples (59.9%) were negative, while 115/287 samples
(40.1%) were positive for LA. 44/115 samples
(38.26%) were positive for both tests (aPTT and
dRVVT), 60/115 samples (52.17 %) were positive
only for dRVVT and 11/115 samples (9.57%) were
positive only for aPTT. LA was confirmed in 9/62
pregnant women samples (14.5 %). 7 (11.3%) had
abnormal dRVVT, the remaining 2 samples were
positive for both tests. S and SP were 57.4 and 94.8
respectively for aPTT (Cephalin), 58.3 and 91.9 for
aPTT (PTT-LA, Stago) and 87.0 and 100 for dRVVT.
Our results demonstrated that despite showing
a low performance regarding sensitivity when compared
to dRVVT, both aPTT tests were able to detect
LA in 47.83% of the positive studies.
Key words: lupus anticoagulant,
specificity,
sensitivity.
Pages :
|
