Volumen: 19 # Number : 1
Publication Date : Enero - Abril Year: 2015
Immune Thrombocytopenia in chlidren younger
than 4 months: institutional experience
Authors: Elena G, D’Aloi K, Veber S, Martinez G,
Amaral D, Rosso D, Cosentini M, Rohr R
Abstract: There have been a little published about the natural course
of primary Immune Thrombocytopenia (ITP) in infants.
We performed a retrospective study between January
2010 to march 2015, 29 children aged 1 to 4 months
than with ITP have been included. We gathered dates
about vaccines and infection history, clinical features
and necessity and response to treatment. There were 17
men and 12 women. The age range was 40 to 113 days,
with a mean of 65 days of life. All children had petechiae
and hematomas of variable amount. The median count of
platelets was 8000/mm3 (1000-70000). Of 29 patients, 5
(17%) had vaccines history, 9 (31%) associated infection
(4 with CMV, 5 with another infection). 23 children (79%)
required any treatment (15 received gamma globulin and
8 gamma globulin and corticoids), the other 6 had none.
Treatment response was achieved between 1 and 19 days,
with a median of 4 days. No one had progressed into
chronic course. ITP is the most frequent hematological
immune disease in childhood (2-6 years), with a short
evolution, a spontaneous recovery within 6 months in the
70% of the cases and a progression to chronic disease in
a only 10 % of the patients after one year from diagnostic.
In our population, children under 4 months accounted
for 20.5%, all of them reached remission within the
first month of diagnosis, without any recurrence or
complication observed.
Key words: immune thrombocytopenia;
infants,
immunglobulin.
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