Volumen: 18 # Number : 3
Publication Date : Septiembre - Diciembre Year: 2014
Outcome Of Patients Activating An Unrelated Donor
Search In Argentina: A Single-Center Experience
Authors: Basquiera A L, Abichain P L,
1García P A, Sturich A G, Damonte J C,
1 Berretta A R,García J J
Abstract: For patients lacking a HLA-identical sibling donor, an
international search for an unrelated donor (UD) must
be initiated. An international UD search was activated
from our center through the Instituto Nacional Central
Único Coordinador de Ablación e Implante (INCUCAI)
for 138 consecutive patients between January 2008 and
June 2013 with hematological malignancies (n=122)
and non-malignant diseases (n=16). The probability of
finding a donor (cumulative incidence) was 47.5% at
six months and 52.7% at 12 months; 63/138 patients underwent
HSCT in a median time of 5.4 months (range
2.8-12.2) after search initiation. Searches initiated three
months or less from diagnosis had more chances to find
a donor (64.8% vs. 48.6%; p=0.034). Cumulative incidence
of relapse/progression after search activation was 35.5% at 6 months and this was the main cause for search
discontinuation. In the multivariate analysis, absence of
disease progression during the search was associated with
better survival after HSCT (HR 0.40; p=0.024). In this
series of Argentinean patients, an appropriate UD was
found in half of the patients that activated an international
search. More than one third of the patients progressed
during the search, which highlights the importance of initiating
it promptly after diagnosis.
Key words: transplantation ,
allograft,
unrelated donors,
relapse.
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