Volumen: 18 # Number : 2
Publication Date : Mayo - Agosto Year: 2014
Trombosis Venosa Profunda en pacientes
infectados por el Virus de la
Inmunodeficiencia Humana.
Rol de la Trombofilia hereditaria
y adquirida y de los factores
de riesgo tradicionales
Authors: Perés Wingeyer S, Oliva S, Chamorro J, Aranda F, Santoro J, Corti M, de Larrañaga G
Abstract: Background and objective: An increase in the incidence of deep venous thrombosis (DVT) has been seen in patients infected with human immunodeficiency virus (HIV); however, there are some controversies regarding to the causes of this finding. The aim of this study was to analyze the role of hereditary and acquired thrombophilia and traditional risk factors in the development of DVT in HIV+ patients.
Materials and Methods: We carried out a prospective case-control survey including 56 HIV+ patients, 17 with confirmed diagnosis of DVT by doppler ultrasound and 39 without DVT (control group). We performed thrombophilia studies and record clinical variables and conventional risk factors for DVT for all patients.
Results: 82.4% of the patients with DVT were suffering from any opportunistic disease and did not have adherence to antiretroviral therapy when they developed DVT. The need to remain at rest, the febrile syndrome, a low count of CD4 + T cells, a low body mass index, the use of intravascular catheters and the fibrinogen levels were significantly associated with the development of DVT (p<0.05). However, no significant association between thrombophilia and development of DVT was found. In a logistic regression analysis, the use of intravascular catheters (odds ratio, OD: 48, p <0.05) and the resting state (OD: 40, p<0.05) turned to be the only predictive variables of DVT.
Conclusions: In this group of HIV+ patients, there was no association between thrombophilia and DVT. Resting and the use of intravascular catheters were the only predictive factors to develop this complication, increasing by more than 40 times the chances of developing DVT.
Key words: Deep Venous thrombosis; HIV;
Highly Active Antiretroviral Therapy ;
Thrombophilia
Pages : 117-125
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