Volumen: 18 # Number : 1
Publication Date : Enero - Abril Year: 2014
Multilineage dysplasia and
Nuclephosmin 1 (NPM-1) mutation
Authors: Courreges V., Pezzola M., Pastoriza S., Fuente M.,
Massone R., Chavarri A., López Ares L.
Abstract: Acute Myeloblastic Leukemia (AML) is a clonal malignant
expansion of myeloid blasts in bone marrow. There are different molecular mutations that can cause similar morphologic changes, although they can imply different
prognosis. Nuclephosmin 1 (NPM-1) is frequently expressed in AML cells. This mutation usually appears in patients without previous history of myelodysplastic-myeloproliferative disease and it is associated to favorable prognosis, in absence of FLT3-ITD1.
Multilineage dysplasia is considered criteria by WHO to classify AML as secondary to myelodysplastic syndromes and is also associated to high risk cytogenetics. However, recent studies2,3 suggest that when multilineage displasia is associated to NPM mutation it does not modify its favorable
prognosis.
We describe the case of a 20 year-old woman diagnosed with AML associated to dysplastic features, normal cytogenetic
and NPM1 mutated.
Key words: Acute Myeloid Leukemia,
Myelodysplasia, Nucleophosmin-1
Pages : 48-52
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