Volumen: 7 # Number : 3
Publication Date : Noviembre - Diciembre Year: 2003
Authors: Mónica T. F. Aixalá.
Abstract: Our purpose was find out the prevalence ß thalassemia trait (ßT<) among the studied hemoglobi-nopathies and its characteristics in our environment. 1936 hemoglobin studies: normal=1347, ßT<=518 (27%), ßT>=5, ß-ȣT=2, αT=5, Lepore=6; AS=31,SS=5, SLepore=1, AC=7, CC=1, SC=1, AD=2, AJ=2, unstable hemoglobins=3. Results in ßT< patients: bA2 4,83 ±1,20%, Hb F 1,44 ±1,03%, RBC 5,81±0,77x10 12/L, Hb 10,67 ± 1,35 g/dL, PVC 0,36±0,04 L/L, MCV 62,42 ± 5,24 fL, MCH 18,52 ±1,99 pg, RDW 17,82±1,60%, Mentzer 10,88±2,07, England-Fraser -0,04±7,87, Srivastava 325,2 ± 66,1. Morphology altera-tions in ßT< patients: microcytosis 100%, hypochromia 100%, basophilic stippling 56%, target cell 7%, acan-thocytosis 44%, schistocytocsis, Howell Jolly, Cabot rings <4%. For ßT<, the acanthocytosis had more incidence among VCM > 69fL and the basophilic stippling among MCV <60 fL. We found a high percentage of normal studies that can be attributed to silent carriers of αT or iron deficiency or patients who presented symptoms carriers hemoglobi-nopathies related. The investigation about the prevalence of the different abnormal hemoglobins and types of tha-lassemia contributes to a knowledge of our population (ethnic composition, migratory waves) and to family planning.
Key words: thalassemia-hemoglobinopathies, microcytosis
Pages : 183-186
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