Volumen: 5 # Number : 3
Publication Date : Noviembre - Diciembre Year: 2001
Authors: Miguel JA Alcón Álvarez, Benajmin Koziner
Abstract: In 1975, De Vita et al using the MOPP (C-MOPP) regimen reported that DL could be cured with QT. In 1979 Jones et al provided evidence arguing that CHOP should be used as first line in DL. In 1986, the SWOG demostrated that CHOP could cure almost 30% of the patients with DL. In 1993 it was publish that the IPI was a reliable prognostic scheme, and the SWOG in a randomized study, proved that CHOP and the 2º and 3º generation QT were equivalent. The parma study convincingly showed that ABMT is superior to QT in relapsed DL. The GELA and Gianni (Milan) in randomized studies comparing QT vs ABMT demostrated that the latter program is superior. The relapsed is the moust important factor of therapeutic failure afther ABMT. There are a number of strategies in order to avoid relapse and improve CR quality, including upgrading the conditioning regimen and combining both, QT plus target therapy antitumor vaccines, adoptive inmunotherapy.
Key words: Lymphoma-Clasification - Prognostic Factor - Treatment - Stem Cell Transplantation
Pages : 199-209
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