Volumen: 22 # Number : Numero Extraordinario XIII Congreso del Grupo CAHT
Publication Date : Septiembre Year: 2018
IV CURSO EDUCACIONAL
DE LA ISTH - BLOQUE 1
PEDIATRÍA |
The neonatal thrombosis paradox
Authors: Nugent D
Abstract: There is no better example of the nuances and short
comings of our laboratory assays to predict bleeding,
than neonatal coagulation. Paradoxically, very
prolonged partial thromboplastin time and protime
assays are the “norm” for a term neonate and maybe
even further prolonged in the premature infant, and
yet these, our very youngest patients, are considered
more likely to experience a thrombotic event, rather
than bleed(1,2). Indeed, based on the most recent
registries, the rate of thrombosis in this age group
is 10 fold that of a child 12 months or greater, with
coagulation studies in normal range(3). Understanding
the shifts from fetal/newborn production of both
clotting factors and those factors responsible for
slowing the rate of thrombus formation, along with
the equally challenging developmental alterations in
platelet function, is key in the proper evaluation of
the high-risk neonate and in determination of optimal
therapy.
Key words: neonatal thrombosis,
stroke,
perinatal risk factors
Pages : 217-224
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