Volumen: 21 # Number : XXIII Congreso Argentino de Hematología
Publication Date : Noviembre Year: 2017
SIMPOSIO CONJUNTO
SAH-CAHT: |
Is really there a place for hematology
in recurrent miscarriage?
Authors: Lancuba S, Grand B, Branzini C, López M, Wolfenson G
Abstract: Recurrent miscarriage (RM) is defined as the loss of
two or more clinical pregnancies - occurs between 1
to 5% of pregnancies. It increases with maternal age.
There is a strong association between embryonic
genetic disorders -known as aneuploidy- and
fetal loss, with incidence over 80%. However, the
frequency of thrombotic disorders, as an etiologic
factor of RM has been overestimated, exposing
patients to unnecessary diagnostic and therapeutic
procedures disregarding scientific evidence given
that antiphospholipid syndrome frequency is less
than 6%. That is why this publication emphasizes
the need to inform patients about the relevance
of embryo aneuploidy as a leading cause for RM,
assessing that risk with available genomic screening
technology. Next generation sequencing and
comparative genomic hybridization array in fetal
tissues and genetic preimplantation screening -PGSare
highly recommended as new diagnostic methods
in RM. The former strategy is cost effective,
time saving and risk reducing of new fetal loss.
Identifying genetic disorders in fetal tissue would
allow to categorize risk groups which could benefit
from antithrombotic therapy.
Key words: recurrent miscarriage,
preimplantation genetic screening,
hematologic disorders.
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