Volumen: 19 # Number : 3
Publication Date : Septiembre - Diciembre Year: 2015
Cup-like nuclei (prominent nuclear invaginations)
in acute mieloblastic leukemia. Asociation
with NPM1 and FLT3 mutations.
Authors: Enrico A , Dick H, Szelagowski M,
Prates V, De Luca T, Milone J.
Abstract: Some acute myeloid leukemias (AML) with genetic
abnormalities have a distinctive morphological
finding. Blast cells have been described with
prominent nuclear invaginations (PNI) called
“cup-like or fishmouth nuclei” associated with
NPM1 and FLT3 mutations. We report the case of
a female patient diagnosed with “de novo” AML,
hyperleukocytosis, cup-like blasts, HLA-DR and
CD34 negative phenotype, normal karyotype and
NPM1 and FLT3-ITD mutations.
Key words: Acute myeloid leukemia,
Cup-like morphology,
NPM1 and FLT3-ITD mutations.
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