Volumen: 18 # Number : 3
Publication Date : Septiembre - Diciembre Year: 2014
OUTCOME OF PATIENTS ACTIVATING AN UNRELATED DONOR SEARCH
IN ARGENTINA: A SINGLE-CENTRE EXPERIENCE
Authors: Ana L. Basquiera , Patricia L. Abichain , Pablo A. García , Gabriela Sturich , Juan C.
Damonte, Adriana R. Berretta , Juan J. García
Abstract: For patients lacking a HLA-identical sibling donor, an international search for an unrelated
donor (UD) must be initiated. An international UD search was activated from our center
through the Instituto Nacional Central Único Coordinador de Ablación e Implante
(INCUCAI) for 138 consecutive patients between January 2008 and June 2013 with
hematological malignancies (n=122) and non-malignant diseases (n=16). The probability of
finding a donor (cumulative incidence) was 47.5% at six months and 52.7% at 12 months;
63/138 patients underwent HSCT in a median time of 5.4 months (range 2.8-12.2) after
search initiation. Searches initiated three months or less from diagnosis had more chances
to find a donor (CI 64.8% vs. 48.6%; p=0.034). CI of relapse/progression after search
activation was 35.5% at 6 months and this was the main cause for search discontinuation.
In the multivariate analysis, absence of disease progression during the search was
associated with better survival after HSCT (HR 0.40; p=0.024). In this series of
Argentinean patients, an appropriate UD was found in half of the patients that activated an
international search. More than one third of the patients progressed during the search,
which highlights the importance of initiating it promptly after diagnosis.
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