Volumen: 19 # Number : 2
Publication Date : Mayo - Agosto Year: 2015
Immunotherapy and Immune Checkpoints
in the Treatment of Multiple Myeloma
Authors: Enrique M. Ocio y María-Victoria Mateos
Abstract: Multiple Myeloma treatment has experienced a significant
revolution in the last decades with the development
of novel agents with novel mechanisms of
action. Among them, one of the main ones has been
the use of immunotherapy, as it is demonstrated by
the efficacy of immunomodulatory agents (IMiDs)
and the promising results of other strategies with
immune bases such as the different monoclonal antibodies
that are being evaluated. In this same line,
the blockade of immune checkpoints with specific
monoclonal antibodies, such as anti-CTLA4 or
anti-PD1, which inhibit this regulators of the immune
system allowing its antitumoral activity, has
demonstrated clear efficacy and has already been
approved for its use in oncology. In this manuscript
we biefly review the mechanism of action of these
immune chekpoints inhibitors and the clinical data
currently available, as well as its promising future
either as monotherapy or, probably better, in combination
with other treatments in Multiple Myeloma.
Key words: Inmunotherapy,
Checkpoints,
Multiple Myeloma
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