Volumen: 19 # Number : 2
Publication Date : Mayo - Agosto Year: 2015
Current immune therapies for hematological neoplasias
Authors: Jarchum I, Basquiera AL, Albarracín F, Cazap N, Dupont J
Abstract: Immune therapies show efficacy against particular
cancer types. The goal of this review is to provide
a summary of the most common immune therapies
(among them, monoclonal antibodies, bi-specific
antibodies, chimeric antigen receptors and others).
Here, we discuss the immunological basis that lead
to the development of these modalities and that
help understand both their high degree of efficacy
and their unwanted side effects. We present clinical
experiences with these therapies. Undoubtedly,
therapies that harness the immune response will
continue to show efficacy against cancer. A better
understanding of the mechanism of action of
immune therapies and of clinical results will allow
their rapid, safe, and successful expansion towards
the treatment of oncohematological disease.
Key words: immune therapies,
monoclonal antibodies,
bi-specific antibodies,
chimeric antigen receptors,
T cells,
adoptive T cell therapy,
checkpoint inhibitors,
cancer.
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