Volumen: 18 # Number : 3
Publication Date : Septiembre - Diciembre Year: 2014
Glucocorticoids dysregulate 20% of the human genome.
Mabs anti-CD20 do not modify the genome, are safer and eficient
Authors: Giuliani R A
Abstract: Glucocorticoids (GCs) up or down-regulates the expression
of thousands of genes by binding to Glucocorticoid
Receptors (GRs). By alternative splicing of its terminal
exons 9α or 9β in the primary transcript and readings
through 8 different Start Codons, the GR gene develops16
isoforms. Each one of them admits 16 dimeric
combinations and 256 homodimeric versions of GR.
Cortisol travels in plasma tied to Cortisol Binding Globulin
(CBG), which modulates its distribution and access
to every cell and tissue of the body. Its cytosol biodisponibility
is determined by 11β-HSD types 1 and 2 enzymes.
The panel and final concentration of GR monomers
and dimers changes according to the differentiation
programme of each cell. The infusión of semisynthetic
GCs totally disorganyze the delicate balance induced
by the hypothalamus on almost 20% of the Human Genome.
Because of it, chronic infusión of semisynthetic
GCs results in more damage than benefit. Antibodies like
anti-CD20, anti-TNF or Anti-BLyS, react
against specific targets on B or T Cells, are more effective
and do not modify the evenly expression of thousands of
Cortisol’s dependent genes.
Key words: GCs Glucocorticoids,
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