Volumen: 18 # Number : 3
Publication Date : Septiembre - Diciembre Year: 2014
HLA System, Hematopoyetic stem cell transplantation
and unrelated donor search
Authors: Morales VH
Abstract: HLA plays a central role in Hematopoietic Stem Cell
Transplantation (HSCT). Hematopoietic stem cell donor
selection has been almost exclusively based on selecting
an HLA identical donor. An HLA-matched sibling is currently
considered the best donor but only 30% of patients
have a related sibling available. For those patients
lacking an HLA-identical or closely matched family donor,
the alternative of unrelated donor options may be
considered. HLA has an impact on engraftment, immune
reconstitution, graft-versus-host disease (GVHD), and
mortality. CBU is an alternative source of HSC that represents
a good option and has less stringent criteria for
HLA matching. Donor search strategy is described in this
review.
Key words: HLA,
Haematopoietic Cells Transplantation,
Umbilical Cord Blood Transplantation,
Unrelated Donors.
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