Volumen: 18 # Number : 2
Publication Date : Mayo - Agosto Year: 2014
Red Cells and Red Cell Disorders
Authors: Arturo M. Musso
Abstract: Erythrocytes participate in cell signaling pathways, as shown in malaria infection and in sickle cell anemia. Mature
erythrocytes lack ribosomes and RNA, but they have several microRNA that fulfill different actions. Eryptosis, or programmed red cell death, occurs in senescence and in survival-threatening injury. Eryptosis is accelerated in several disorders. Iron-restricted erythropoiesis is present in: 1) absolute iron deficiency; 2) iron-sequestration due to hepcidin production; 3) functional iron deficiency; and 4) other molecular defects of iron metabolism. In patients with iron deficiency anemia refractory to oral treatment, a complete gastrointestinal investigation is mandatory. In order to study functional iron deficiency it is advisable to measure: 1) percentage of hypochromic red cells; 2) reticulocyte
MCH; and/or 3) reticulocyte hemoglobin content.
These parameters are given by different instruments. Hyperferritinemic Syndrome is not always associated to iron overload. Erythroferrone is an erythroid factor that represses hepcidin during increased erythopoiesis.
Key words: red cells, eryptosis, iron deficiency
Pages : 151-155
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