Volumen: 17 # Number : Suplemento
Publication Date : Octubre Year: 2013
Immunotherapy
in pediatric hemato-oncology
Authors: G. Lucchini, E. Rettinger, P. Bader
Abstract: Immunotherapy has progressively acquired an important
role in the treatment of children with refractory/
resistant hemato-oncological diseases. Its ultimate goal is that of increasing the immunological
driven anti-cancer effect without causing further immunological complications. Recent experience has made clear some basic principles in the use of immunotherapy: it has a better success rate when applied in the pre-emptive setting and it should be preceded by lymphodepletion. It is, therefore, reasonable
to think that the stem cell transplantation setting could be a perfect match for this kind of therapy. The present review summarizes some of the many different strategies that are currently under pre-clinical and clinical evaluation, mostly in the pediatric field, and hints at their possible application in the allogeneic stem cell transplantation setting.
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