Volumen: 17 # Number : 2
Publication Date : Mayo - Agosto Year: 2013
Authors: Corti M., Villafañe M.F.
Abstract: AIDS-associated malignancies have not escaped to the changes that have occurred in the last two decades regarding with the clinical manifestations of the disease. During this time there have been changes in the incidence, type and natural history of malignancies in HIV-infected subjects. Since widespread
use of highly active antiretroviral therapy (HAART), non-Hodgkin lymphomas (NHL) have shown changes in its epidemiology and currently represent a major challenge for infectologists and onhcohematologists. Classically, AIDS-associated lymphomas were associated with a severe immunodeficiency,
usually occurring in individuals with CD4 T cell counts below 200 cells T/μL and in those
with a history of AIDS-defining diseases. In this scenario, the relative risk of develop a NHL is 100 to 200 times higher than in the general population. Although the use of HAART has been associated with a significant decrease in the incidence of some opportunistic infections and Kaposi’s sarcoma, this is not as clear in the case of NHL and Hodgkin lymphoma
in HIV- positive patients.
Key words: HIV, AIDS, lymphomas
Pages : 153-158
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