Volumen: 16 # Number : 3
Publication Date : Septiembre - Diciembre Year: 2012
Authors: Béguelin Kehoe P., Freitas J., Oliveira N.
Abstract: disease characterized by clonal proliferation of hematopoietic
precursor cells. This results in the disruption
of normal hematopoiesis and bone marrow failure. The
most important prognostic factors include cytogenetic
and molecular markers, and patient age. However, most
patients have a normal karyotype at diagnosis making it
difficult to predict long-term evolution.
Genetics alone cannot explain the diversity of phenotypes
within a population, nor the different susceptibilities
of its members to certain diseases. Epigenetics
emerges as a bridge between genetic interactions and
the environment. It involves therapeutically reversible
changes at the level of gene expression without changes
in the sequence of DNA (deoxyribonucleic acid).
Current chemotherapy treatments induce complete
remission in 70 to 80% of patients but most of them
relapse and die.
Epigenetic modifications could potentially be used as
prognostic factors in early diagnosis, predictors of both
response to drug treatment and disease progression, and
may be used as therapeutic targets.
Key words: epigenomics, leukemia myeloid acute,
methylation, acetylation, microRNA.
Pages : 176-184
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