Volumen: 16 # Number : 2
Publication Date : Mayo - Agosto Year: 2012
Authors: Bezares R.F.(*), Ledesma I.L.(*), Solessi .M.(*), Frigeri .E.(#), Diaz A.E.(*),
Pantano J.L.(*), Cambiazzo S.(*), Giordano M.(^), Gamberale R.(^),
Servidio M.(#), Iparragirre M.J.(#), Calcagno M.L.(o) y Fideleff H.L.(#)
Abstract: Chronic lymphocytic leukemia is the most common
type of adult leukemia in the West and is characterized
by great variability of presentation and response to treatment.
Recently several papers have been published suggesting
that vitamin D plays a role in the pathogenesis,
progression and even the response to cancer treatment.
In order to analyze the values of vitamin D in a cohort
of CLL patients and its implications in time to request
treatment we analyzed samples of 57 patients. In this
cohort values of vitamin D were compared with prognostic
factors available for most of the centers in our area
(LDH, β2-microglobulin, ZAP-70, CD38) and Binet stage
at diagnosis. A relationship between Vitamin D deficient
values and increased LDH and β2-microglobulin (p =
0.022 and p = 0.08) as well as a shorter time of treatment
was demonstrated. The hazzard ratio (HR = 2.606)
allowed us to infer that patients with this deficiency
are 2.6 times more likely to initiate treatment. So far
the value of vitamin D seems to be the only modifiable
prognostic factor, so this finding could change the
natural history of the disease.
Key words: CLL, Prognostic factors, D vitamin
Pages : 79-85
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