Volumen: 2 # Number : 2
Publication Date : Mayo - Agosto Year: 1998
Pathogenesis and treatment of plastic anemia
Authors: Bruce M. Camitta M.D., Rebecca Jean Slye Profesor of Pediatric Hematology - Oncology
Abstract: Aplastic anemia is a group of hematologic disorders characterized by peripheral blood pancytopenia and a hypocellular bone marrow. Hematopoietic stem cells are decreased and the residual cells are often functionally defective. A preponderance of evidence suggests that aquired aplastica anemia is immunologically mediated: activated T-lymphocytes produce increased quantities of y-interferon and tumor necrosis factor which result in supression of hematopoiesis. Choise of initial treatment for a patient with plastic anemia depends upon a complex interaction berween patient age, disease severity and the avalability of a bone marrow donor. Patients with mild discase, either immunosuppression or bone marrow transplantation are indicated. As our knowledge of the pathogenesis of aplastic anemia improves, more effective, less toxic treatments should become available.
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Pages : 63-67
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