Volumen: 2 # Number : 2
Publication Date : Mayo - Agosto Year: 1998
Authors: Adamczuk Y., Forasteiro R., Martinuzzo M., Carreras LO
Abstract: Autoantibodies directed to beta2 glycoprotein I (aß2GPI) are frequently found in patients with antiphospholipid antibodies (aPL). They are more strongly associated with clinical manifestations of the antiphospholipid syndrome than aPL. Its has been shown that αß2GPI are considered a better marker of clinical complications of ntiphospholipid syndrome that the presence of aPL. It has been shown that ß2GPI and C4b binding protein (C4bBP) share certainhomology. In a previous study we have show that anticardiolipin antibodies were asociated with a plasma decrease of C4bBP. The aim of the present study was to evaluate in 131 patients with aPL whether the decrease of C4bBP is related to the presence of αß2GPI. Lower C4bBP levels (mean ± SD) in the group of patients having αß2GPI (n = 57) were obserbed when compared with the normal group (n = 44) (73.4% ± 94.6% vs 28.1 ± 20.9, p <0.005). The differences was more significant considering the IgG isotype. The group of patients with positive αßGPI -IgG (+) (n = 41) had lower values of C4bBP (70.1% ± 26.8) than both the normal group (p <0.005 ) and the group pf 2GPI-IgG (- n = 90, 86.0% ± 30.5, P <0.005). The difference C4bGP (levels <70%) was more frequent in ß2GPI α-IgG (+) (63.4%) than in ß2GPI α-IgG (-) (34.4%, P <0.005). It was also found that patients with aPL and a history of nus thrombosis (n = 32) had lower levels C4bßP (75.1% ± 27.9) compared with the normal group (p <0.005). The mechanism C4bßP decrease has not been clarified yet. The finding of altered C4bßP/proteína S system, mainly in patients with αß2GPI could explain, at least in part, the increased risk of thrombosis in patients with these autoantibodies.
Antibodies directed against beta2 glycoprotein I (aß2GPI) are recognized as one of the most frequent autoantibodies in patients with antiphospholipid antibodies (aPL). The αß2GPI are considered a better marker of clinical complications of antiphospholipid syndrome that the presence of aPL. Because 2GPI roteína C4b binding (C4bBP) have some structural homology and base of C4bBP disminusión associated with anticardiolipin antibodies found in a previous study, was evaluated in 131 patients with aPL if disminusión of C4bBP was associated with the α ß2GPI. Antigen levels (mean ± SD) C4bBP enores hey were in the group of patients with α ß2GPI (n = 57) compared with the normal group (n = 44) (73.4% ± 94.6% vs 28.1 ± 20.9, p <0.005). The differences were even more significant when considering the IgG isotype: the gupo ßGPI α-IgG (+) (n = 41) had lower values of C4bBP (70.1% ± 26.8) than the gupo normal (p <0.005 ) and the group of patients with negative αß2GPI-IgG (- n = 90, 86.0% ± 30.5, P <0.005). The difference C4bGP (levels <70%) was more frequent in ß2GPI α-IgG (+) (63.4%) than in ß2GPI α-IgG (-) (34.4%, P <0.005). It was also found that patients with aPL and a history of venous thrombosis (n = 32) had lower levels C4bßP (75.1% ± 27.9) compared with the normal group (p <0.005). The mechanism C4bßP decrease has not been clarified yet. The finding of altered C4bßP/proteína S system, mainly in patients with αß2GPI could explain, at least in part, the increased risk of thrombosis in patients with these autoantibodies.
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Pages : 51-57
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