Volumen: 6 # Number : 1
Publication Date : Enero - Abril Year: 2002
Authors: Anahí Vijnovich Baron, Elena De Mateo, Paola Chabay, Marta Dragosky, Jose Porta, María V. Preciado
Abstract: Background: Hodgkins's Lymphoma (HL) has a bimodal age-incidence curve. In developed countries, HL shows low incidence among and peaks by age 30, meanwhile, in developing countries exhibits the first peak in childhood. In both types of countries there is invariably a second peak above 50 years of age. Epstein Barr virus (EBV) asociation with HL has been well documented in different reports. Our purpose is to perform a comparative analysis of EBV presence in adult and pediatric HL. Design: 79 pediatric and 65 adult formalin fixed paraffin embedded lymph node biopsies and 1 sleen were studied for the presence of EBV using EBERs in situ hibridization and latent membrane protein -1 (LMP -1) immunohistochemical labeling. The patient's age range and sex distribution were: children 2-15 years (median: 8), 76,5% male and adults 16-80 years, (median: 38) 51% male. Results: EBV detection a) pediatric population: 42+ cases (53%), 67% correspondig to mixed cellularity subtype (MC) (p=0,01), one of them was diagnosed as interfollicular MC. Particulary in the subgroup younger than 7 years old showed 74% EBV + cases (p=0,006). B) adult population: 18 (27%) EBER+ cases by in situ hybridisation. 55,5% corresponding to MC and 33% to nodular sclerosis subtype. Interestingly, 1EBV+ case was a lymphocyte-rich and another one was in the spleen. Conclusion: 1) EBV-HL association was more common in children than in adults. (53% vs 27%) which is coincident with previous reports. 2) The subgroup of patients younger than 7 years old showed very high association (74%), 3) EBV presence in both groups was similar to the EBV association of HL reported in developed countries, 4) Both in pediatric and adult groups MC was predominant EBV associated subtype. 5) In the adult population EBV association was different between public hospital (38%) and private practice (20%) groups.
Key words: comparative study, EBV, Hodking's Lymphoma, adult, pediatric.
Pages : 8-12
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