Volumen: 22 # Number : Numero Extraordinario XIII Congreso del Grupo CAHT
Publication Date : Septiembre Year: 2018
Optimal duration of secondary prevention of VTE
Authors: Ageno W
Abstract: Recurrent venous thrombosis may occur within
the first few days or weeks, but also after several
months or years after the index event. Observational
studies have reported that up to 40% of patients will
experience a recurrence after 8 to 10 years(1). The
incidence rate of recurrent VTE was estimated to
be about 5.0% patient-years, being highest during
the first 6 months (11.0% patient-years) and then
decreasing with a plateau at 2.2% patient-years
between 4 and 10 years after the index event(2).
Recurrence rates are highest in patients with
permanent predisposing factors, such as active
cancer, and lowest in patients with major, removable
predisposing factors such as surgery(3,4). In between,
there are several subgroups of patients including
those with chronic inflammatory diseases, patients
with non-surgical removable risk factors such as
hormonal therapy or acute medical illness, and
patients with unprovoked VTE(5). It was proposed
that a recurrence rate of 5% at one year and of 15%
at five years after stopping anticoagulant therapy can
be considered acceptable to justify discontinuation
of vitamin K antagonists (VKAs), whereas higher
recurrence rates should mandate continuation of
treatment
Key words: vitamin K antagonists,
direct oral anticoagulants,
venous thromboembolism.
Pages : 50-53
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